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Why is Ozone Therapy Useful For So Many Different Diseases?

The use of ozone gas as a therapy in the health field has attracted some skepticism due to its unstable molecular structure. However, ozone therapy has been researched in-depth pertaining to its biochemistry, physiological and pharmacological knowledge and effect. Literature has shown that ozone is highly valued for various effects, such as being antimicrobial, anti-hypoxic, analgesic, immune modulating etc. on various biological systems.

You may have noticed that ozone seems to be useful in treating a myriad of pathologies:

  • Infectious diseases (bacterial, viral, fungal and parasitic)
  • HIV-1 infection
  • Chronic Hepatitis B and C
  • Herpetic infections and Herpes Zoster
  • Papillomavirusinfections
  • Colds and flus
  • Dysmetabolic syndrome
  • Ischemic diseases
  • Retinal degenerative disorders
  • Neurodegenerative diseases
  • Autoimmune diseases
  • Cancer
  • Anti-ageing
  • Overuse of antibiotics or antibiotic resistance
  • Dermatological diseases
  • Pulmonary diseases
  • Chronic fatigue syndrome and fibromyalgia
  • Emergency situations, pre and post-surgery
  • Dentistry and oral medicine

The question is, why?

Ozone (O3) is an unstable oxidizing molecule consisting of three oxygen atoms. Some of you may have heard that ozone is toxic for inhalation and there are numerous cases describing its detrimental effects. This statement is true. Our alveolar surface in the lungs is protected by a small amount of antioxidant content, which is insufficient in extinguishing the strong oxidant activity of ozone. In other words, your lungs simply don’t have enough antioxidants to deal with the potent power of this oxidative therapy.
Nevertheless, the exact opposite is true for our blood and internal components as both our plasma and blood cells have a remarkable quantity of cooperating antioxidants. When administered ozone reacts within seconds with the organic components such as cells, blood, viruses, bacteria etc. and generates a number of chemical messengers responsible for activating crucial biological functions.

What are these crucial biological functions?

1. Ozone increases oxygenation

Ozone has demonstrated its effect in the regulation of the oxygen metabolism and oxygenation. When administered, ozone increases the content of free dissolved blood oxygen – resulting in production of energy and re-establishing the normal metabolic functions. Ozone improves systemic oxygenation by significantly and constantly increasing oxygen availability and microcirculation. In regards to cancer, ozone mediated hyperoxia (refers to a state of sufficient oxygen) inhibits and counteracts the hypoxia inducing factor therefore reducing angiogenesis and improving radiotherapy and chemotherapy.

2. Ozone improves antioxidant systems

In response to ozone a mild – moderate oxidative stress occurs which activates Nrf2. Nrf2 then induces the transcription of antioxidant response elements resulting in the production of antioxidant enzymes including – superoxide dismutase (SOD), catalase and glutathione peroxidase. Both these free and antioxidant enzymes not only protect from oxidation and inflammation but they can reverse chronic oxidative stress.

3. Ozone improves energy levels

Ozone therapy increases ATP production. It is also a powerful mitochondrial stimulant. Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased reactive oxygen species production in mitochondria. Any Nrf2 activator, was found to promote mitophagy, thereby contributing to the overall mitochondrial homeostasis.

4. Ozone is anti-inflammatory

Inflammation is induced via NFκB activation by various inflammatory factors such as severe oxidative stress. Antioxidants and anti-oxidative enzymes not only protect cells from oxidation and inflammation but they may be able to reverse the chronic oxidative stress. Ozone therapy activates Nrf2 via moderate oxidative stress, and suppresses NFκB and inflammatory responses.

5. Ozone is anti-bacterial, anti-viral and anti-fungal

Ozone therapy produces a direct oxidative effect on bacteria, viruses, fungi and protozoa. This oxidative effect has a damaging consequence on the microorganism’s membrane.
Ozone interferes with the metabolism of bacterium-cells, through inhibition and by blocking the operation of the enzymatic control system. A sufficient amount of ozone breaks through the cell membrane, and this results in the destruction of the bacteria. Indirectly this activates the immune response. Unlike bacteria, viruses multiply only within the host cell. They transform protein of the host cell into proteins of their own. Ozone destroys viruses by diffusing through the protein coat into the nucleic acid core which results in viral RNA damage. At higher concentrations, ozone affects the DNA structures of the microorganism.

6. Ozone is analgesic

“The analgesic effect of ozone is provided by oxidation of the products of albuminolysis, the so-called lgopeptides that act on the nerve endings in the damaged tissue and determine the intensity of pain response”. In addition to that, analgesic effects are also caused by a normalization of the antioxidant system, a reduction in inflammation and improved oxygenation.

7. Ozone supports detoxification

Ozone therapy activates the metabolic processes in the hepatic and renal tissues, thus ensuring their main function of neutralization and elimination of toxic compounds.

8. Ozone improves elasticity of red blood cells

Ozone can decrease the thickness and viscosity of blood that would make it easier for circulation and also stimulate dilation and relaxation of the artery walls. It was observed that ozone had a statistically significant decrease in plasma total cholesterol and low-density lipoprotein. Ozone reduces platelet aggregation and makes red blood cells more elastic and flexible.

9. Ozone immune modulating effects

In particular the hydrogen peroxide produced from ozone is a crucial mediator in host defense and immune response. The enhancement of the immune function followed by ozone therapy is also due to the induced production of cytokines.

When addressing disease, it is important to identify the root cause resulting in ill health. To do this effectively, it requires an individualized approach to understand each person’s unique genetic, biochemical and lifestyle factors. The causes of a disease vary from person to person however several general components which ozone address are often implicated:

  • Inflammation
  • Poor oxygenation and circulation
  • Toxins
  • Infections
  • Mitochondrial function
  • Low antioxidant status

Additionally, other causes are implicated in disease including but not limited to: unhealthy diet, poor lifestyle choices, stress and trauma, deficiencies, specific organ weakness, dental hygiene, DNA impairments, acidity and alkalinity.

In almost all disease states the crucial biological functions that ozone provides have a beneficial result. Ozone covers multiple aspects within the one therapy which is why it is such a favorable choice. Furthermore, ozone therapy is systemic providing an effect on the whole body. In saying that, ozone therapy is not the cure you’ve been looking for but rather a powerful adjunct therapy and prevention tool for many conditions. Ultimately, removing the root cause of disease is imperative to ensure long lasting health, prevention and re-occurrence.

Includes: 1 x Ozone Generator with 5 year warranty, 6 OZONE OILS, 1.5m silicon hose, 1 x International power supply and plugs, 1 Flow Regulator (medical or industrial), 2 x Ozone Insufflation Bags, 10 x Ozone Catheters, 1 x Limb Ozone Bag with in/outlet, 1 x MnO3 Ozone Destruct Unit, 2 x 60ml Syringes, 6 x Luerlock connectors AND MORE!

References

Bocci, V., Zanardia, I., Valacchi, G., Borrelli, E., & Travagli, V. (2015). Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases. Cardiovascular & Hematological Disorders-Drug Targets, 15(2), 127–138. https://doi.org/10.2174/1871529×1502151209114642

Cakir, R. (2014). General Aspects of Ozone Therapy. In Pharmacology and Nutritional Intervention in the Treatment of Disease(Vol. i, p. 13). InTech. https://doi.org/10.5772/57470

Zanardi, I., Borrelli, E., Valacchi, G., Travagli, V., & Bocci, V. (2016). Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity. Current Medicinal Chemistry,23(4), 304–314. https://doi.org/10.2174/0929867323666151221150420

Mauro, R. Di, Cantarella, G., Bernardini, R., Rosa, M. Di, Barbagallo, I., Distefano, A., … Volti, G. L. (2019). The biochemical and pharmacological properties of ozone: The smell of protection in acute and chronic diseases. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/ijms20030634

Bocci, V. A. (2006). Scientific and medical aspects of ozone therapy. State of the art. Rivista Italiana Di Ossigeno-Ozonoterapia, 5(2), 93–104. https://doi.org/10.1016/j.arcmed.2005.08.006

Borrelli, E., & Bocci, V. (2007). Basic Biological and Therapeutic Effects of Ozone Therapy in Human Medicine. Ozone Science and Technology. Retrieved from http://www.eolss.net/outlinecomponents/ozone-science-technology.aspx

Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research, 1(1), 29. https://doi.org/10.1186/2045-9912-1-29

Elvis, A., & Ekta, J. (2011). Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine, 2(1), 66. https://doi.org/10.4103/0976-9668.82319

Smith, A. J., Oertle, J., Warren, D., & Prato, D. (2015). Ozone Therapy : A Critical Physiological and Diverse Clinical Evaluation with Regard to Immune Modulation , Anti-Infectious Properties , Anti-Cancer Potential , and Impact on Anti-Oxidant Enzymes, (August), 37–48.

Diseases, S. O. (1996). Does Ozone Therapy Normalize the Cellular Redox Balance ? Implications for the Therapy of Human Immunodeficiency Virus Infection and Several Other Diseases, 150–154.

Lin, Y., Juan, H., & Cheng, Y. (2007). Ozone exposure in the culture medium inhibits enterovirus 71 virus replication and modulates cytokine production in rhabdomyosarcoma cells, 76, 241–251. https://doi.org/10.1016/j.antiviral.2007.07.004

Review, S. (2009). Oxygen-Ozone Therapy in Medicine : An Update, 373–376. https://doi.org/10.1159/000236365

Menéndez, S., Cepero, J., & Borrego, L. (2008). Ozone therapy in cancer treatment: State of the art. Ozone: Science and Engineering, 30(6), 398–404. https://doi.org/10.1080/01919510802473724

Artis, A. S., Aydogan, S., & Sahin, M. G. (2010). The effects of colorectally insufflated oxygen-ozone on red blood cell rheology in rabbits, 45, 329–336. https://doi.org/10.3233/CH-2010-1316

Clavo, B., Santana-rodriguez, N., Llontop, P., Gutierrez, D., Ceballos, D., Méndez, C., … Fiuza, D. (2015). Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients, 2015.

Guanche, D., Zamora, Z., Hernández, F., Mena, K., Alonso, Y., Roda, M., … Gonzales, R. (2010). Effect of ozone / oxygen mixture on systemic oxidative stress and organic damage, 20(November 2009), 25–30. https://doi.org/10.3109/15376510903503107

Article, R., Joshi, S., Garg, S. K., & Sharma, P. (2014). Ozone Therapy: An Appreciable cure in the Treatment of Back Pain, 1(2), 18–29.

V., B., & V., T. (2009). May oxygen-ozone therapy improves cardiovascular disorders. Cardiovascular and Hematological Disorders – Drug Targets. https://doi.org/10.2174/187152909788488681

Martínez-Sánchez, G., Delgado-Roche, L., Díaz-Batista, A., Pérez-Davison, G., & Re, L. (2012). Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease. European Journal of Pharmacology, 691(1–3), 156–162. https://doi.org/10.1016/j.ejphar.2012.07.010

Hernández, F., Menéndez, S., & Wong, R. (1995). Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radical Biology and Medicine, 19(1), 115–119. https://doi.org/10.1016/0891-5849(94)00201-T

Plessis, L. H., Westhuizen, F. H. Van Der, & Kotze, H. F. (2007). The effect of blood ozonation on mitochondrial function and apoptosis of peripheral blood mononuclear cells in the presence and absence of plasma antioxidants. Journal of Biotechnology,6(August), 1763–1769.

Bocci, V., Zanardi, I., & Travagli, V. (2011). Oxygen / ozone as a medical gas mixture . A critical evaluation of the various methods clarifies positive and negative aspects. Medical Gas Research, 1(1), 6. https://doi.org/10.1186/2045-9912-1-6

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