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CBD Suppositories vs CBD Vape

If you grew up like me knowing that marijuana is a drug that makes you dependent and is the start of a life as a junky, you may have missed over 2000 research studies that proof the beneficial effects of this plant.

Like most herbs, Majijuana has over 400 different chemical constituents of which Cannabidiol (CBD) is one of the most researched and beneficial for our body.

In the following blue tabs you find well known facts about CBD and you are welcome to study them with all the research but my purpose today is slightly different. I would like to look at CBD from a different and more practical angle. 

Therapeutic Potential of CBD

It has been mentioned several times that cannabis compounds have therapeutic potential. But, what sort of benefits does CBD actually have? What qualities make the cannabinoid beneficial for health?

Research suggests that CBD is:

  • Anti-inflammatory
  • Analgesic
  • Antioxidant
  • Antispasmodic
  • Antiemetic
  • Antipsychotic
  • Antiepileptic
  • Vasorelaxant
  • Immunosuppressant
  • Neuroprotective
  • Antimicrobial
  • Antifungal

The compound can also have a mild energizing effect in small doses, while perhaps providing more sedative effects in larger doses.

How CBD works

Over the past eight decades, scientists have uncovered that CBD acts as a regulator of the endocannabinoid system (ECS). The ECS is a large neurotransmitter network that helps the body and brain communicate with each other.

In many ways, the ECS is a bridge that helps the conscious mind make sense of the surrounding environment. The ECS plays a role in a variety of bodily functions, including:

  • Sleep/wake cycle
  • Movement
  • Cognition
  • Mood
  • Memory
  • Pain perception
  • Pleasure
  • Metabolism
  • Reproduction
  • Bone growth
  • Immune response

The ECS is made up of cell receptors that sit on the surface of cells (cannabinoid receptors) and the molecules that connect with these receptors (endocannabinoids). Endocannabinoids are like the body’s own cannabis. In this case, Endo- refers to internal. The active compounds in cannabis are phytocannabinoids. Phyto- refers to plants.

CBD works by tapping into the ECS, modulating its effects. It is a compound that can alter concentrations of neurotransmitters in the nervous system. It can also affect the immune system and other bodily functions, like bone growth.

CBD has the following effects on different diseases

1. Epilepsy

Research on CBD for epilepsy is by far the most advanced in terms of clinical research. Already, one biopharmaceutical company has created a CBD-based anti-epileptic drug called Epidiolex.

Invented by Britain's GW Pharmaceuticals, Epidiolex contains isolated CBD. Thus far, it has been successful in phase 3 clinical trials in both Dravet’s Syndrome and Lennox-Gastaut Syndrome.

Both conditions affect pediatric patients and are often unresponsive to conventional pharmaceutical treatments. These conditions often lead to premature death and can cause dozens of seizures each day.

Successful phase 3 trials are the final steps in approving new epilepsy drugs for medical use.

In one trial, researchers tested the effects of CBD on 120 children aged two to 18. The peer-reviewed study was published in 2017 in the New England Journal of Medicine.

The trial found that CBD successfully reduced seizures in 43 percent of the test subjects by greater than half. On average, those given CBD experienced a seizure reduction from 12.6 to 5.9 per month.

Those given placebo went from 14.9 to 14.1 per month.

Five percent of patients given CBD had their seizures disappear completely. This did not happen at all with the placebo group.

2. Cancer

A growing body of preclinical evidence and one early trial suggests that CBD has potent anti-cancer properties. In laboratory and rodent models of breast cancer, the cannabis compound has successfully caused tumor cells to self-destruct.

This occurs through a process called apoptosis, which can be described as “cell suicide”.

Normal cells will undergo apoptosis naturally if they are damaged or diseased. However, for some reason, cancer cells stop responding to signals that trigger cell suicide. This means that cancer cells can continue to grow and proliferate.

CBD is expected to be most effective for breast cancer cells, though several other types of cancer cells have responded to the cannabinoid in preclinical research.

In early 2017, GW Pharmaceuticals again tested the effects of a cannabis-based drug on 21 patients with glioblastoma multiforme, an aggressive form of brain cancer. The participants were treated with a drug that contained both psychoactive THC and CBD.

Patients in the study also received chemotherapy.

The phase 2 clinical trial found that those treated with the cannabis-based drug had a one-year survival rate of 83 percent. Those given a placebo had a one-year survival rate of 53 percent.

Patients treated with the cannabis medicine survived a median number of 550 days compared with only 369 days for those given placebo.

3. Psychiatric disorders

Feeling blue or overly anxious? CBD can help.

Research suggests that CBD may be a useful tool in the treatment of psychiatric disorders. Preclinical studies have found that CBD has anti-anxiety and antidepressant properties.

However, early clinical trials have also found that CBD-based medications have shown signs of success in treatment-resistant schizophrenia.

While psychoactive THC is not considered helpful for those with psychotic disorders, CBD is non-psychotropic. In fact, preclinical research suggests that CBD may actually dampen the psychoactive properties of THC.

These same characteristics are perhaps what makes CBD a compound of interest in schizophrenia research.

Yet again, GW Pharmaceuticals has successfully completed a phase 2 clinical trial testing the effects of CBD in 88 patients with schizophrenia. CBD was given as an adjunct treatment along with conventional antipsychotic medications.

The trials found that the CBD-based drug successfully reduced both positive and negative symptoms of the disorder, as well as improved cognition when paired with conventional treatments.

4. Inflammatory disorders

Inflammation is a culprit in a wide variety of diseases, yet it is particularly problematic in autoimmune disease. Ample preclinical research suggests that CBD may be useful in the treatment of various inflammatory disorders.

Experimental research suggests that the endocannabinoid system is an emerging player in the area of inflammation.

While researchers are still unraveling the complex entanglements between the ECS and the immune system, the preliminary evidence provides positive signs that CBD may successfully reduce inflammation that contributes to several different diseases, including:

  • Depression
  • Diabetes
  • Alzheimer’s disease
  • Neuropathic pain
  • Rheumatoid arthritis
  • Metabolic disease

5. Diabetes

A phase 2 trial published in Diabetes Care tested the effects of cannabinoid-based drugs in 62 patients with type 2 diabetes. The drugs contained both CBD and another cannabis compound, tetrahydrocannabivarin (THCV).

Researchers found that CBD reduced resistin, which is a compound that contributes to the buildup of belly fat.

CBD also increased levels of a compound called glucose-dependent insulinotropic peptide. This peptide is thought to boost insulin secretion. In type 2 diabetes, cells stop responding to insulin and patients need to supplement with the hormone in order to maintain blood sugar levels.

The overall results of the study did not reach the clinical goals. However, these findings suggest that there is still reason to continue to explore CBD in diabetes research.

In rodent models, CBD treatment has been found to lower insulin resistance in non-obese mice, as well as halt the development of autoimmune diabetes in non-obese mice.

6. Neurological conditions

The stress-fighting and anti-inflammatory effects of CBD may make it particularly useful for neurological conditions and diseases of aging.

Preclinical research suggests that CBD may be helpful in slowing the progression and treating symptoms of neurological and degenerative conditions like Alzheimer’s diseaseParkinson’s disease, and multiple sclerosis(MS).

Already, a prescription drug containing both psychoactive THC and CBD is available for multiple sclerosis patients in many countries. The drug is Sativex and it was developed by GW Pharmaceuticals.

Sativex has been found to be effective in easing pain and reducing spasticity and tremors associated with MS. MS is a degenerative disorder that causes the fatty lining of nerve cells in the brain to deteriorate.

Research suggests that CBD may provide long-lasting protection against the deterioration of nerve cells by reducing inflammation.

7. Brain trauma

Believe it or not, the U.S. government has a patent (US6630507) on the use of cannabinoids as neuroprotective antioxidants. Antioxidants are compounds that prevent damage to cells and DNA.

As a neuroprotective antioxidant, CBD may be useful in checking back damage caused by brain injuries. These neuroprotective qualities also make the compound useful in the treatment of the neurodegenerative disorders mentioned above.

Currently, the biopharmaceutical company Kannalife Science has exclusive rights to the U.S. patent and hopes to develop therapies to both prevent and help patients recover after brain damage.

While investigations are still underway, preclinical evidence suggests that pretreatment with CBD may reduce the damage caused by traumatic brain injury. Additional evidence suggests that CBD treatment post-stroke mayimprove recovery after the event.

Side Effects of CBD

Although there have been several studies that show that CBD is effective in treating a range of disorders and diseases, there are still side effects just like many other types of treatment. However, patients often find that the benefits of CBD far outweigh the side effects. Some of the more common side effects are as follows:

  1. Dry mouth: One of the most common side effects in users is that they experience a dry mouth. Researchers believe the endocannabinoid system’s involvement in saliva secretion causes this.
  2. Low Blood Pressure: In very high doses, users of CBD often find that they experience a drop in their blood pressure. This usually happens within a few minutes of the molecule entering the body. When this happens, users report that they feel slightly lightheaded. It’s important that you consult with your doctor before taking CBD if you are already taking medicine for blood pressure.
  3. Drowsiness: If you are taking higher doses of CBD, you may find that it causes you to become drowsy or sleepy. If you ever feel this way, it’s important that you do not operate heavy machinery.

For patients experiencing any of the disorders or diseases that we discussed, it’s important to do your research before taking CBD. With that said, there have been several studies that show that CBD is highly effective and safe in treating symptoms in these disorders. As CBD becomes more and more accepted across the United States and the world, you can expect to see increased availability of research on the topic. If you decide to use CBD to treat your symptoms, we encourage you to consult with your doctor first.

CBD is an extract of the marijuana plant which contains as said before over 400 chemical compounds. The main compounds are

THC is the part that gets you high. THC binds to cannabinoid receptors in the central nervous system and the immune system, resulting in relaxation, reduced pain, and increased appetite. THC is helpful for treating many, many ailments. Studies have shown that it has medicinal benefits for ALS (Lou Gehrig’s disease), Alzheimer’s, anxiety, arthritis, chemotherapy side effects, Crohn’s Disease, chronic pain, fibromyalgia, HIV-related peripheral neuropathy, Huntington’s Disease, incontinence, insomnia, multiple sclerosis, pruritus, sleep apnea, and Tourette Syndrome, among others. THC has even been shown to kill cancerous tumors!

THCA is THC before it has been heat treated to unfold the psycho active form. A growing number of patients and caregivers, led by Dr. William Courtney of Mendocino County, are learning the benefits of juicing raw, fresh cannabis. Dr. Courtney believes THCa has medicinal properties that are lost when the plant is dried, and it can be metabolized in much larger doses than THC, making it potentially more effective. THCa is reported to have anti-proliferative and anti-inflammatory abilities, which show potential to inhibit the growth of cancerous cells. Its anti-spasmodic properties that help subdue muscle spasms may explain the success some of our patients are reporting controlling seizures.

CBD and interest in its effects is growing. It is non-psychoactive. It has been reported to have anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea, anti-rheumatoid arthritic and sedative properties. CBD is used to help with acne, ADD, anxiety, arthritis, cancer, chronic pain, depression, diabetes, Dravet syndrome, epilepsy, glaucoma, Huntington’s Disease, inflammation, mood disorders, multiple sclerosis, neuropathic pain, Parkinson’s, schizophrenia, and neurodegenerative diseases such as Alzheimer’s.CBD has also been shown to stop the spread of cancer cells.

CBN (cannabinol) is created when THC is exposed to light and oxygen. It’s known to have some mild psychoactive effects, and it appears to increase the effects of THC. CBN’s primary reported effects are as an anti-epileptic, anti-spasmodic and reliever of intraocular pressure. Recent studies suggest that CBN can be administered as an antidepressant, can be used to prevent convulsions and to sedate patients experiencing pain.

CBC ( the anti-inflammatory and anti-viral effects of cannabis, and may contribute to the overall analgesic effects of medical cannabis. CBC may have potential to inhibit the growth of cancerous tumors due to its interaction with anandamide, an endocannabinoid known to fight breast cancer. Studies suggest CBC works best in conjunction with CBD and THC to create a synergistic effect.

So when you use only CBD you miss out on the other properties of THC, THCA, CBC and CBN.

As you can see there are great benefits in using them all, but the psycho-active factors may be what scares you off. It is difficult to live a normal life when you are a bit light headed and possibly too relaxed to bother with mundane things in life. Plus “munchies” may be not good for your BMI.

That taken aside I would always go for the real thing. If it's legal in your country you can follow the same rules as described below and vape a nice indica bud cultivated with a lot of CBD or make the extract from Rick Simpson and use it rectally. The effects can be very joyful.

CBD Absorption & Wear Off

To find the best delivery method is important because CBD is not cheap. You definitely want to have the greatest effects for your money. That's why we should look at the 2 most prominent versions. From the chart below you see that inhalation of CBD vape delivers almost 99% while rectal insufflation leads before all other methods by 82%.  Both methods are superior to anything else but have different effects.

Inhaling Vaped CBD

When CBD is inhaled, its effects last for the shortest time in comparison to other methods. Even the best CBD vape oil will not last as long as CBD suppositories or an extract administered orally. But therefore you absorb 99%.

It is always good when you have a CBD vape pen with you for emergency situations to deal with pain, stress, anxiety, seizures, epilepsy and so on. It will calm you down and help you deal with every situation. Because it lacks a psychedelic effect you will not be impaired during the day.

The greatest benefit is that you can dose very easily and feel the effects very fast. Just take a pull of the vape pen and feel the effects take place almost instantly. The transport of CBD into the lungs and blood is almost instantaneous.

CBD Suppositories

The second best absorption of CBD is via rectal suppositories and the wear off is super slow. This means you have the highest availability of large doses of CBD in your system and a long lasting effect.

This is ideal for night and sleep time. Think about the fact that your body heals during the night and detoxifies all organs in the process. This is when you need most of the healing energy CBD can offer. You also provide the biggest support to your immune system.

In several cancer clinics patients receive around 4 pm their CBD suppositories. Some get one dose to help sleep and heal faster while others got 2 or even 3 x 250 mg of CBD if apoptotic effects were observed. Not all patients experience the dying off of cancer cells but some do and in these cases larger quantity was administered. Mostly breast cancer seems to be most responsive.

if you live in AU or NZ why don't you send an email to [email protected] We may be able to help you get some.

Will CBD work for YOUR problem? 

While researching CBD you will find many reviews of people who have no effects while others rave about stunning results. Some had all problems disappear while others feel nauseated and unwell.

It is always hard to know in advance if and how a remedy works for you. That's why trying is the key. You need to experiment and find out what works for you. You also need to be persistent with a remedy and give it a chance to work. If you have bacterial overgrowth for example and CBD starts killing a lot of bacteria you may feel worse before you feel the improvement.

Another factor is the root cause of your disease. I assume you are not suffering from a cannabis deficiency. You have a reason that triggers your disease and prevents a recovery. What is it that makes you sick?

There are only 5 main causes that can make you sick and CBD will only work for some of them.

STRESS

The probably biggest factor in any disease development is stress. Whether it's prolonged stress at work and relationship or chronic stress from disease or trauma, it's by far the greatest culprit for a suppressed immune system. This is where CBD will have the greatest effect. It helps to relax and see the world through different eyes. Sometimes it's just a shift in perspective which then solves a problem.

Another factor of CBD induced sleep is that you are able to resolve emotional problems in your rem cycles at night. Learning, transforming theory into experience, resolving conflict and finding solutions to your daily problems is the main task of the 5 rem (rapid eye movements) cycles at night. You consolidate your memory in these states of half sleep. These cycles are immensely enhanced by CBD and will help you deal with life much wiser.

At first you may experience intense dreams, restless sleep and may be even fear but this usually fades when your body and mind have worked through some of the trauma and conflict you need to resolve.

DEFICIENCIES

I would not really call CBD a supplement because it will not help you in case you are deficient in minerals, vitamins, phytonutrients, amino and digestive acids. The whole plant freshly juiced would be better for the purpose of supplementation.

TOXINS

We have learned that you only detoxify during the night while you sleep deeply. CBD will therefore help your body to detoxify by first removing you and your overactive mind from the equation and second because the energy CBD provides helps your immune system to perform a much better work. Your white blood cells have many CBD receptors and get fully activated when motivated by this herb.

So even though CBD is not a detox agent, it supports your natural detox process immensely. This fact is also the main reason why taking Answered Prayers Evening Ceremony in the afternoon is so beneficial. It prepares you for sleep and gives you the energy that is needed to do the job during the night.

INFECTIONS

CBD has natural antibiotic properties and even works on antibiotic resistant bacteria and different viral infection. It is therefore super important that in cases of Lyme disease or other infectious diseases CBD is used in strong concentrations.

Many cancers go hand in hand with different infections which indicates that when you kill the infection you kill the cancer. On top of that connects THC to the CB1 or CB2 cannabinoid receptor sites on a cancer cell and causes an increase in ceramide synthesis which drives cell death. CBD therefore calls forth an apoptotic effect in cancer cells. The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. How elegant is that?

OXYGEN DEPRIVATION

One of the most ignored and neglected causes of disease is the lack of oxygen in your system. When you think of oxygen together with glucose to be the engine in your car where all ATP is produced, you can understand that Oxygen deprivation is responsible for the lack of energy in every bodily system. You can't function on optimal levels.

CBD just like Ozone has an energising effect on all of your cells. Your red blood cells become fully inflated ready to take up oxygen and deliver it via the smallest capillaries it into all organs and tissue. Your immune cells are activated to work more efficiently and your body energy levels increase.

Research:

  • Nice informative post.

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