09
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The REAL Super Antioxidant – Cellular Glutathione

What is it? Why do we need it? How do we get it? 

Antioxidants are a very fashionable selling point at the moment. Every street corner sells some a type of new super smoothie drink containing extra antioxidants. However what actually are antioxidants? What do they do for us?

Believe it or not, Oxidization is a process you are all familiar with. The most commonly seen physical representation is rust. When Iron oxidizes (is exposed to oxygen) a chemical reaction occurs leading to rust and damage. Within our bodies we are also prone to oxidative (oxygen reaction) damage. Oxidative damage is an ongoing process in our body due to our necessity for oxygen. The level of oxidative damage present in the body is used as a marker for overall health. As oxidative damage increases, numerous functions in the body begin to decline, leading to an increased risk of malfunction (autoimmune, cancer) and disease (immune suppression). Furthermore, nutrients (macro and micro nutrients), which are required for life, may be damaged or de-natured in the body or prior to consumption by oxidization.

The primary free radical responsible for oxidization is Reactive Oxygen Species (ROS). Although oxygen facilitates the chemical reaction that damages cells and nutrients, the quantity of free radicals is increased by external perpetuators such as chemicals, toxins, radiation, poor nutrition and lack of exercise.

Before we condemn all free radicals and eat mountains of antioxidants, let us note that ROS also functions as an important messenger in the body and in the right doses leads to a healthy immune response and associated reactions.

So we’ve established that one of the factors in achieving optimum health is the correct balance of free radicals/ROS.

Fresh fruits, vegetables, seeds, nuts, grains and spices contain antioxidants in varying quantities. Polyphenol rich fruits such as berries are very high in antioxidants and when we consume these foods they reduce ROS activity in the body. Therefore, as scientific evidence uncovers the damaging effects of free radicals, more and more products with increasingly high antioxidant levels have hit the markets.

So how has our body survived this long without all these super berry smoothies?images

Despite these food sources containing substantial levels of antioxidants, our bodies actually naturally produce a far more superior antioxidant called Glutathione (GSH) (pronounced “gloota-thigh-own”).

Glutathione is an intracellular antioxidant and is considered our master antioxidant. It is one of the primary molecules responsible for quenching free radicals such as ROS. Uniquely, Cellular Glutathione has the ability of maximizing the performance of all the other antioxidants, including vitamins C and E, CoQ10, alpha-lipoic acid, as well as the fresh vegetables and fruits that you eat every day.

Glutathione's primary function is to protect your cells and mitochondria from oxidation and peroxidation damage. It is also essential for detoxification, energy utilization and preventing the diseases we associate with ageing. Cellular Glutathione also eliminates toxins from your cells and gives protection from the damaging effects of radiation, chemicals and environmental pollutants.

Below are just 10 of the functions that glutathione plays in the body. 

  1. GSH reacts with various physiological metabolites such as, estrogen, prostaglandins, leukotrienes and chemicals, such as bromobenzene and counteracts acetaminophen overdose.
  2. GSH interacts with Nitric oxide and both have critical roles regulating lipids, glucose and amino acid utilization.
  3. GSH is involved with the removal of the carcinogen, Formaldehyde from the body.
  4. GSH is required for the prostaglandin H2 pathways.
  5. GSH inhibits Influenza virus infection.
  6. GSH is involved in many other important metabolic pathways, including protein metabolism.
  7. GSH is required for the proliferation of cells, including lymphocytes and intestinal epithelial cells.
  8. GSH plays an important role in spermatogenesis and sperm maturation, thus highly important for those trying to conceive.
  9. GSH is essential for the activation of T-lymphocytes and polymorphonuclear leukocytes and is required for cytokine production.
  10. GSH is important for successful immune responses when the host is immunologically challenged.
  11. GSH is involved in the process of maintaining Vitamin C and E in the active metabolic forms.

As seen from the list above GSH is one of the most critical molecules of the entire body. As the most important intracellular antioxidant, GSH regulates all other antioxidants while helping to prevent damage from ROS, such as free radicals and peroxides.

The good news is that your body produces its own Cellular Glutathione. However, the bad news is that poor diet, pollution, toxins, medications, stress, trauma, ageing, infections and radiation all deplete your glutathione to a point where the body cannot keep up with the level of oxidation occurring.

Therefore, maintaining optimal Cellular Glutathione levels is empirical to health. The body produces glutathione out of a combination of three simple proteins or amino acids; cysteine, glycine and glutamine. Along with these proteins which are found in a wide variety of foods, vitamin B6 (pyridoxine) and vitamin C are also vital for its production and recycling. Furthermore, the Methylation cycle is a precursor to glutathione production and thus also requires the primary methylation vitamins Folate and B12 (methylcobalamin).

These nutrients are readily available in a healthy, whole food diet. However due to environmental influences and modern lifestyles, these nutrients are commonly found to deficient in many individuals.  As the prevalence of glutathione deficiency is rampant the targeted dietary sourcing or supplementation of these nutrients is imperial to maintain a high standard of health.

There is a large array of glutathione containing supplements currently on the market. However, what most people don’t know, is that commonly sold supplemental glutathione is not readily utilized within the body. This is due to the lack of constituents that facilitate the transport of GSH into the bloodstream and through cell membranes. Thus, most of the GSH you will find on the shelves will unlikely result in any therapeutic benefits.

Although intra venous (IV) glutathione is well studied and boasts astounding results, it is not accessible by everyone. Luckily, after some extensive trials, researches have found that by administering Cellular Glutathione GSH via the sublingual pathway, intracellular levels were dramatically increased. A product was formulated that contains both bio available Cellular Glutathione GSH plus the necessary constituents to allow the body to form its own.

Recommended Cellular Glutathione SupplementACG

Due to the associated clinical trials and formulation, ACG Glutathione Extra Strength from Results RNA is Truly Heal’s supplement of choice.

ACG Glutathione Extra Strength is an intra-oral Cellular Glutathione spray GSH that tastes great and has been proven by an independent clinical research firm to effectively increase intracellular levels of GSH by over 10% in only 7 hours.

The significant efficacy of ACG Glutathione Extra Strength is achieved by atomized spray delivery, sub mucosal absorption and the instant bioavailability of key molecules at the cellular level.

 

References

Ballatori et al (2009) Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009 March; 390(3): 191–214.
Sies, H. (1999) Glutathione and its cellular functions. Free Radic. Biol. Med. 27:916-921.
Guoyao Wu2, Yun-Zhong Fang, Sheng Yang, Joanne R. Lupton, and Nancy D. Turner. (2004) Glutathione Metabolism and Its Implications for Health.  Am. Soc. Nut. Sci.
Townsend, D. M., Tew, K. D. & Tapiero, H. (2003) The importance of glutathione in human disease. Biomed. Pharmacother. 57:145-155.
Fang, Y. Z., Yang, S. & Wu, G. (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872-879.
Lei, X. G. (2002) In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice. Methods Enzymol. 347:213-225.
Cai, J., Chen, Y., Seth, S., Furukawa, S., Compans, R. W. & Jones, D. P. (2003) Inhibition of influenza infection by glutathione. Free Radic. Biol. Med. 34:928-936.
Lu, S. C. (2000) Regulation of glutathione synthesis. Curr. Top. Cell Regul. 36:95-116.

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